Liquid Chromatograph-Mass Spectrometry

Liquid chromatograph-mass spectrometry (LC/MS) is an indispensable tool for quantitative and qualitative analysis in a wide range of fields, from pharmaceuticals and food science to environmental analysis.

Whether you are looking to maximize throughput, increase sensitivity for trace compound analysis, or install a compact LC/MS system in a smaller lab space without losing out on workflow efficiency, Shimadzu provides a range of world-class LC/MS instruments and applications to meet your daily analysis needs. Unique automation features and intuitive software ensure a smooth analysis experience for both beginners and experts.

Browse Shimadzu's full product range below.

Time of Flight Instruments (Q-TOF)


The Q-TOF model LCMS-9050 is the perfect tool for cutting-edge research applications that require high sensitivity, high speed, and high resolution analysis. With fast polarity switching and double speed in MS/MS, it offers an environment where highly reliable analytical data can be acquired more easily.


The Q-TOF model LCMS-9030 is a mid-range quadrupole time-of-flight LC/MS performance. With its fast MS/MS capabilities, it is designed for routine targeted and untargeted sample analysis, it will enable screening, comprehensive profiling, and structural elucidation/identification of unknowns.

Triple Quadrupole LC-MS/MS Instruments


The LCMS-8060NX is a triple quadrupole mass spectrometer with world-class sensitivity and detection speeds. It boasts increased robustness and ease of use as well as Analytical Intelligence to maximize your laboratory’s output.


The LCMS-8060 is a ground breaking innovation in mass spectrometry helping to transform LC/MS/MS...


Experience a New Realm of High-Sensitivity & High-Speed Performance...


Accomplishes Both High Sensitivity and Ultra-High-Speed Detection   Equipped with a...


LCMS-8040 Enhanced Sensitivity  ...

Single Quadrupole LCMS Instruments


The LCMS-2050 provides both high speed and high sensitivity analysis even in a small design. We have achieved the utmost in both miniaturization and high performance with Shimadzu's technology cultivated over many years of MS development. A single platform, a single solution for LC detection, the LCMS-2050 has the power to deliver better results with incredible simplicity and unparalleled robustness.


Ultra high-speed mass spectrometer compatible for the first time with ultra high-speed liquid...


Direct Probe Ionization Mass Spectrometer. The DPiMS-2020 is a single quadrupole mass...

Single Quad Preparative LCMS

Utilizing patented ultrafast technology, the LCMS-2020 mass spectrometer delivers more information about your preparative runs, and enables you to collect the right peak.

LCMS Medical Devices

LCMS In Vitro Diagnostic (IVD) Medical Devices

 Mass Spectrometry and Liquid Chromatography components for in vitro diagnostic applications

Solutions/Accessories for LCMS TQ & HRMS


CLAM-2040 is an online automated sample preparation module that brings LCMS smoothly into your laboratory.


Fully Automated Sample Preparation Module for LCMS™ Based on Shimadzu's Extensive Experience...

C2MAP System

New Cell Culture Media Analysis Platform for Fundamental Research and...

Direct Probe Ionization Mass Spectrometer Kit

PESI ion source for LCMS TQ for direct analysis of sample without sample prep and separation ...

Nexera MX

Higher throughput is of the utmost importance to laboratory efficiency and profitability. Nexera MX...

Nexera Mikros

Micro: Above and Beyond Nano   The High Sensitivity You Expect from a Low Flow...

LDTD™ Ion Source Option for LCMS-8050/8060

The laser diode thermal desorption (LDTD)™ ion source as option for the LCMS TQ range ...

Trap-Free 2D LC/MS sytem for Quadrupole LCMS

A dedicated solution for impurities quantitation in Pharmaceutical field ...


The DPiMS QT probe electrospray ionization kit is attached to a quadrupole time-of-flight MS ...

LC-MS Columns & Consumables


LabSolutions Insight Biologics

LabSolutions Insight Biologics is software for analyzing the characteristics of oligonucleotides using the LCMS-9030 or LCMS-9050 quadrupole time-of-flight type (Q-TOF) mass spectrometer.

LabSolutions Insight Library Screening

LC/MS/MS Screening Software

Solution System Packages

High Resolution Accurate Mass Library for Forensic Toxicology

The High Resolution Accurate Mass (HRAM) Library includes two MS/MS spectral libraries. Each library is built using two different separation conditions and is suitable for targeted or non-targeted screening of drugs of abuse, psychotropic drugs, pharmaceuticals, pesticides, and other compounds of toxicological interest.

LC/MS/MS Method Package for Reactive Sulfur Profiling

This LC/MS/MS Method Package for Reactive Sulfur Profiling offers analytical methods for LC/MS/MS that target all 17 sulfur-containing metabolites, including reactive sulfur species, with separation conditions and MS parameters that are optimized for each compound.

LC/MS/MS Method Package for Glycosaminoglycan

Provides Sample Preparation Protocols and Analytical Methodsfor Glycosaminoglycans that Cause Mucopolysaccharidosis

LC/MS/MS Method Package for Steroid Hormones

Provides Sample Pretreatment Protocols and Analytical Methods for Steroid Hormones

Sample preparation tools

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